Table 2 Linkage analysis of the PTPN22-1858T allele to rheumatoid factor-seropositive (RF+) rheumatoid arthritis (RA) using the transmission disequilibrium test (TDT)
Families | Transmission [% (n)] | P |
|---|---|---|
TDT RA sample 1 | ||
TDT RA index cases (n = 100) | 66 (55) | 0.022 |
TDT RA index cases RF+ (n = 81) | 66 (47) | 0.029 |
TDT RA index cases RF- (n = 19) | 63 (8) | 0.48 |
TDT RA sample 2 | ||
TDT RA index cases (n = 100) | 53 (57) | 0.69 |
TDT RA index cases RF+ (n = 76) | 56 (43) | 0.45 |
TDT RA index cases RF- (n = 24) | 43 (14) | 0.59 |
All TDT RA families | ||
All TDT RA index cases (n = 200) | 59 (112) | 0.059 |
All TDT RA index cases RF+ (n = 157) | 61 (90) | 0.037 |
All TDT RA index cases RF- (n = 43) | 50 (22) | 1 |