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Table 3 Association of PTPN22 genotypes carrying the 1858T allele and rheumatoid factor-seropositive (RF+) rheumatoid arthritis (RA)

From: Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele

 

PTPN22 genotypes [% (n)]

P a

Odds ratio (95% confidence interval)

 

C/C

C/T

T/T

C/T or T/T

  

TDT RA sample 1

      

   All TDT RA index cases (n = 100)

65 (65)

31 (31)

4 (4)

35 (35)

  

   Controlsb (n = 100)

79 (79)

20 (20)

1 (1)

21 (21)

0.029

2.05 (1.07–3.81)

   TDT RA index cases RF+ (n = 81)

64 (52)

31 (25)

5 (4)

36 (29)

  

   Controlsb (n = 81)

79 (64)

20 (16)

1 (1)

21 (17)

0.038

2.1 (1.04–4.24)

   TDT RA index cases RF- (n = 19)

68 (13)

32 (6)

0

32 (6)

  

   Controlsb (n = 19)

79 (15)

21 (4)

0

21 (4)

0.71

 

TDT RA sample 2

      

   All TDT RA index cases (n = 100)

69 (69)

27 (27)

4 (4)

31 (31)

0.76

 

   Controlsb (n = 100)

71 (71)

26 (26)

3 (3)

29 (29)

  

   TDT RA index cases RF+ (n = 76)

68 (52)

28 (21)

4 (3)

32 (24)

  

   Controlsb (n = 76)

74 (56)

24 (18)

2 (2)

26 (20)

0.47

 

   TDT RA index cases RF- (n = 24)

71 (17)

25 (6)

4 (1)

29 (7)

  

   Controlsb (n = 24)

63 (15)

33 (8)

4 (1)

37 (9)

0.76

 

All TDT RA families

      

   All TDT RA index cases (n = 200)

67 (134)

29 (58)

4 (8)

33 (66)

  

   Controlsb (n = 200)

75 (150)

23 (46)

2 (4)

25 (50)

0.078

 

   TDT RA index cases RF+ (n = 157)

66 (104)

29 (46)

5 (7)

34 (53)

  

   Controlsb (n = 157)

76 (120)

22 (34)

2 (3)

24 (37)

0.047

1.69 (1.03–2.78)

   TDT RA index cases RF- (n = 43)

70 (30)

28 (12)

2 (1)

30 (13)

  

   Controlsb (n = 43)

70 (30)

28 (12)

2 (1)

30 (13)

1

 
  1. RF-, seronegative for rheumatoid factor.
  2. aFollowing data previously reported in RA and because of the infrequency of the PTPN22-1858T/T genotype, it was combined with the 1858C/T genotype for the analysis.
  3. bControls derived from nontransmitted parental chromosomes.