Skip to main content

Table 3 TNF-RII T676G single nucleotide polymorphism genotype frequencies and sTNFR levels

From: Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis

Genotype n (%) sTNF-RI (pg/ml) sTNF-RII (pg/ml)
Early RA
TT 63 (61.2) 1,503 ± 704 4,690 ± 1,961
TG 33 (32.0) 1,451 ± 370 3,961 ± 1,242
GG 7 (6.8) 1,094 ± 240 3,648 ± 697
Established RA
TT 91 (60.3) 1,816 ± 705 5,837 ± 2,219
TG 51 (33.7) 1,633 ± 642 5,375 ± 1,921
GG 9 (6.0) 1,700 ± 570 5,187 ± 1,066
  1. Shown are tumour necrosis factor receptor II (TNF-RII) T676G single nucleotide polymorphism (SNP) genotype frequencies and soluble tumour necrosis factor receptor (sTNFR) levels in rheumatoid arthritis (RA) patients with early (n = 103) and established (n = 151) disease. sTNFR levels are expressed as the mean ± standard deviation. Multiple regression analyses of log transformed data corrected for age, sex and disease duration revealed a significant trend of decreasing soluble tumour necrosis factor receptor I (sTNF-RI) and sTNF-RII levels across the genotypes (order: TT > TG > GG) of patients with established disease (P for trend = 0.01 and P for trend = 0.03, respectively). A similar nonsignificant trend was seen for patients with early disease (P = 0.3 and P = 0.055, respectively).