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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

Figure 5

NF-κB and AP-1 binding sites within the Cyp7b promoter. Putative binding sites for selected transcription factor family matrices were identified using the MartView export function. Sequences for putative binding sites are underlined. *, transcription start side; -, presence of the transcription binding site on the minus DNA strand; AP-1, activator protein-1; Cyp7b, cytochrome p450 enzyme 7b; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor-κB; STAT, signal transducer and activator of transcription.

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