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Table 3 Effects of adjuvant arthritis on B vitamin status during inflammation in rats

From: Inflammation causes tissue-specific depletion of vitamin B6

Component Adjuvant arthritis (n = 18) Control (n = 20) P
Baseline
   Plasma pyridoxal 5'-phosphate (nmol/L) 793.9 ± 191.3 744.2 ± 145.4 0.89
   Urinary 4-pyridoxic acid (μg/d) 30.8 ± 17.3 30.0 ± 18.9 0.89
Acute inflammation
   Plasma pyridoxal 5'-phosphate (nmol/L) 252.0 ± 62.5 480.9 ± 144.0 <0.0001
   Urinary 4-pyridoxic acid (μg/24 h) 27.7 ± 14.9 32.9 ± 17.2 0.249
   Liver pyridoxal 5'-phosphate (nmol/g) 22.6 ± 1.7 27.4 ± 4.9 0.035
   Skeletal muscle pyridoxal 5'-phosphate (nmol/g) 7.7 ± 1.8 7.2 ± 0.9 0.88
Chronic inflammation
   Plasma pyridoxal 5'-phosphate (nmol/L) 324.2 ± 91.6 393.7 ± 143.5 0.033
   Urinary 4-pyridoxic acid (μg/24 h) 31.1 ± 11.8 27.1 ± 14.2 0.39
   Liver pyridoxal 5'-phosphate (nmol/g) 21.1 ± 3.0 31.7 ± 4.7 0.0001
   Muscle pyridoxal 5'-phosphate (nmol/g) 8.7 ± 4.8 6.4 ± 2.5 0.907
  1. Data are presented as means ± SD. Day 21 represents the acute inflammation condition; day 42 represents the chronic inflammation condition. Bold P values are statistically significant.