Table 3 Effects of adjuvant arthritis on B vitamin status during inflammation in rats
From: Inflammation causes tissue-specific depletion of vitamin B6
Component | Adjuvant arthritis (n = 18) | Control (n = 20) | P |
|---|---|---|---|
Baseline | |||
   Plasma pyridoxal 5'-phosphate (nmol/L) | 793.9 ± 191.3 | 744.2 ± 145.4 | 0.89 |
   Urinary 4-pyridoxic acid (μg/d) | 30.8 ± 17.3 | 30.0 ± 18.9 | 0.89 |
Acute inflammation | |||
   Plasma pyridoxal 5'-phosphate (nmol/L) | 252.0 ± 62.5 | 480.9 ± 144.0 | <0.0001 |
   Urinary 4-pyridoxic acid (μg/24 h) | 27.7 ± 14.9 | 32.9 ± 17.2 | 0.249 |
   Liver pyridoxal 5'-phosphate (nmol/g) | 22.6 ± 1.7 | 27.4 ± 4.9 | 0.035 |
   Skeletal muscle pyridoxal 5'-phosphate (nmol/g) | 7.7 ± 1.8 | 7.2 ± 0.9 | 0.88 |
Chronic inflammation | |||
   Plasma pyridoxal 5'-phosphate (nmol/L) | 324.2 ± 91.6 | 393.7 ± 143.5 | 0.033 |
   Urinary 4-pyridoxic acid (μg/24 h) | 31.1 ± 11.8 | 27.1 ± 14.2 | 0.39 |
   Liver pyridoxal 5'-phosphate (nmol/g) | 21.1 ± 3.0 | 31.7 ± 4.7 | 0.0001 |
   Muscle pyridoxal 5'-phosphate (nmol/g) | 8.7 ± 4.8 | 6.4 ± 2.5 | 0.907 |