|
Strain
|
Anti-hG6PI versus score
|
Anti-CII versus score
|
n
|
|---|
| |
Rho
|
P value
|
Rho
|
P value
| |
|---|
|
C3H.NB
|
0.917*
|
0.009*
|
0.793*
|
0.026*
|
9
|
|
B10.Q
|
0.402*
|
0.046*
|
-0.094
|
0.614
|
26
|
|
(B10.Q × DBA1)F1
|
0.018
|
0.956
|
0.139
|
0.67
|
10
|
|
DBA/1
|
0.317
|
0.370
|
0.033
|
0.924
|
10
|
- To investigate correlations between arthritis severity and antibody production the Spearman correlation test was applied. Mice of indicated strains were immunized with 200 μg glucose-6-phosphate isomerase (G6PI) in complete Freund's adjuvant. Blood was drawn at day 40 and analyzed by ELISA for anti-hG6PI and anti-CII total IgG responses, as shown in Fig. 1. The accumulative arthritis score until day 40 was tested for correlation with antibody production using the Spearman rank correlation test. A rho value close to 1 indicates correlation of high ranks for IgG with high ranks for arthritis scores; 0 indicates that there is no correlation between values; and a number close to -1 indicates that high ranks for one variable correlate with low ranks for the other. *Significant positive correlations.
