From: Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ12,14prostaglandin J2
Agonist added
A 580
Percentage of control
None (control)
0.81 ± 0.05
100
IL-1β (10 ng/ml)
1.12 ± 0.04*
138
15d-PGJ2 (10 μM)
0.91 ± 0.07
112
IL-1β + 15d-PGJ2
1.10 ± 0.05
135
Rosiglitazone (10 μM)
0.95 ± 0.09
117
IL-1β + rosiglitazone
1.12 ± 0.07