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Table 1 Effects of peroxisome-proliferator-activated receptor γ agonists on viability of IL-1β-stimulated chondrocytes

From: Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ12,14prostaglandin J2

Agonist added

A 580

Percentage of control

None (control)

0.81 ± 0.05

100

IL-1β (10 ng/ml)

1.12 ± 0.04*

138

15d-PGJ2 (10 μM)

0.91 ± 0.07

112

IL-1β + 15d-PGJ2

1.10 ± 0.05

135

Rosiglitazone (10 μM)

0.95 ± 0.09

117

IL-1β + rosiglitazone

1.12 ± 0.07

138

  1. 15d-PGJ2, 15-deoxy-Δ12,14prostaglandin J2.
  2. *, P < 0.05, comparison with non-stimulated controls