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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

Figure 3

Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilage. Paraffin sections of knee joints of young (5 months old) and old (2 years old) mice were stained immunohistochemically with antibodies against TGF-beta1, TGF-beta2 or TGF-beta3. Subsequently, the number of cells staining positive in the cartilage were scored with a computerized imaging system and corrected for the total number of cells. (a) In medial cartilage, TGF-beta2 and TGF-beta3 expression were significantly reduced with age. (b) In lateral cartilage, TGF-beta2 was significantly reduced. Error bars display the standard error. For statistical analysis, a Student's t-test was used. * = p < 0.05.

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Arthritis Research & Therapy

ISSN: 1478-6362

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