Clinical effect of NF-κB inhibitor DHMEQ on collagen-induced arthritis in DBA/1J mice. After onset of arthritis, animals were treated with 100 μg/day dehydroxymethylepoxyquinomicin (DHMEQ; ■; n = 10) or vehicle (□; n = 10). (a) Sum of the thickness of the right and the left hind paws of each mouse after 2 weeks of treatment. Each paw was measured twice and the average was plotted. (b) Sum of the number of swollen joints (described in the Materials and methods section) in the right and the left hind paws of each mouse after 2 weeks of treatment. Each paw was counted twice and the average was plotted. Maximum possible number is 32 per mouse. (c) Change in body weight of each mouse during the first week of treatment. Horizontal bars represent the mean. NF-kB, nuclear factor-κB.