Suppression of VCAM-1 expression by DHMEQ. Suppression of vascular cell adhesion molecule (VCAM)-1 expressed on tumor necrosis factor (TNF)-α-stimulated rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) by dehydroxymethylepoxyquinomicin (DHMEQ). Flow cytometric analysis was carried out (as in Fig. 7) except that anti-VCAM-1 antibody was used. (a) Representative data are shown, along with (b) the means ± standard deviation of VCAM-1-positive cells in three independent experiments.