Figure 1

Prevalence of circulating CD3⁺CD4⁺CD28^null and CD3⁺CD8⁺CD28^null cells in ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. (a) Representative example showing the prevalence of CD3⁺CD4⁺CD28^null T cells (percentage out of C3⁺CD4⁺) and CD3⁺CD8⁺CD28^null T cells (percentage out of C3⁺CD8⁺). The histogram shows staining for CD3 (filled grey curve) and isotype control antibody (black line). Dot plots are then gated on CD3⁺ cells. (b) Box plots summarize the prevalence of CD3⁺CD4⁺CD28^null and CD3⁺CD8⁺CD28^null T cells in ankylosing spondylitis (AS), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) patients. The Mann-Whitney U test was used to determine the statistical differences between patients and the age-matched healthy control group (CO). ***P < 0.001.