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Table 2 Genotype frequencies in UK Caucasian and North Indian/Pakistani rheumatoid arthritis patients and healthy controls

From: Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B

Gene

Genotype

UK Caucasian

North Indian/Pakistani

  

Control (n = 129)

RA (n = 147)

P

Nodular RA (n = 37)

P

Control (n = 128)

RA (n = 123)

P

FCGR2A-131

RR

39 (0.31)

40 (0.28)

0.81

7 (0.19)

0.36

25 (0.19)

30 (0.25)

0.15

 

RH

59 (0.47)

72 (0.49)

 

21 (0.58)

 

66 (0.52)

48 (0.39)

 
 

HH

28 (0.22)

34 (0.23)

 

8 (0.22)

 

37 (0.29)

44 (0.36)

 

FCGR3A-158

FF

68 (0.48)

59 (0.39)

0.15

12 (0.31)

0.02

63 (0.49)

48 (0.38)

0.21

 

FV

61 (0.43)

69 (0.46)

 

17 (0.45)

 

57 (0.44)

66 (0.52)

 
 

VV

12 (0.09)

22 (0.15)

 

9 (0.24)

 

9 (0.07)

12 (0.10)

 

FCGR3B-NA

22

48 (0.37)

55 (0.38)

0.13

16 (0.43)

0.28

49 (0.39)

47 (0.39)

0.25

 

21

72 (0.56)

71 (0.48)

 

16 (0.43)

 

45 (0.35)

53 (0.43)

 
 

11

9 (0.07)

21 (0.14)

 

5 (0.14)

 

33 (0.26)

22 (0.18)

 

FCGR2B-1206

GG

56 (0.48)

67 (0.46)

0.96

16 (0.43)

0.19

61 (0.48)

58 (0.47)

0.98

 

GA

50 (0.42)

63 (0.43)

 

13 (0.35)

 

54 (0.43)

54 (0.44)

 
 

AA

12 (0.10)

16 (0.11)

 

8 (0.22)

 

11 (0.09)

11 (0.09)

 
  1. Values are expressed as number (%). RA, rheumatoid arthritis.