Table 3 Reactivity in ELISA of sera from mothers of groups I and II
Antigen | Systemic lupus erythematosus | Sjögren's syndrome | Asymptomatic | ||||
|---|---|---|---|---|---|---|---|
Group I (%) | Group II (%) | P | Group I (%) | Group II (%) | P | Group I (%) | |
Recombinant Ro52 protein | 97 | 66 | 0.009* | 67 | 98 | 0.027* | 31 |
1–13 MASAARLTMMWEE | 77 | 46 | 0.084 | 47 | 58 | 31 | |
10–25 MWEEVTPICLDPFVE | 0 | 14 | 0 | 0 | 0 | ||
12–35 EEVTCPICLDPFVEPVSIECGHSF | 10 | 16 | 20 | 8 | 13 | ||
25–40 EPVSIECGHSFCQECI | 0 | 13 | 10 | 0 | 6 | ||
34–56 SFCQECISQVGKGGGSVCAVCRQ | 0 | 1 | 7 | 0 | 13 | ||
38–53 ECISQVGKGGGSVCAV | 3 | 4 | 7 | 0 | 0 | ||
50–64 VCAVCRQRFLLKNLR | 25 | 3 | 13 | 5 | 6 | ||
63–79 LRPNRQLANMVNNLKEI | 0 | 6 | 0 | 3 | 0 | ||
77–94 KEISQEAREGTQGERCAV | 18 | 1 | 3 | 0 | 0 | ||
93–116 AVHGERLHLFCEKDGKALCWVCAQ | 40 | 12 | 10 | 9 | 0 | ||
94–109 VHGERLHLFCEKDGKA | 3 | 13 | 0 | 0 | 0 | ||
107–122 GKALCWVCAQSRKHRD | 69 | 28 | 0.023* | 47 | 33 | 13 | |
107–126 GKALCWVCAQSRKHRDHAMV | 37 | 7 | 0.062 | 13 | 8 | 13 | |
121–137 RDHAMVPLEEAAQEYQE | 0 | 4 | 0 | 0 | 0 | ||
135–151 YQEKLQVALGELRRKQE | 3 | 14 | 0 | 0 | 0 | ||
149–166 KQELAEKLEVEIAIKRAD | 0 | 12 | 0 | 1 | 0 | ||
164–180 RADWKKTVETQKSRIHA | 0 | 9 | 0 | 0 | 6 | ||
178–193 IHAEFVQQKNFLVEEE | 3 | 14 | 0 | 0 | 0 | ||
191–208 EEEQRQLQELEKDEREQL | 0 | 0 | 0 | 0 | 0 | ||
206–224 EQLRILGEKEAKLAQQSQA | 0 | 1 | 7 | 0 | 9 | ||
222–235 SQALQELISELDRRCHS | 17 | 3 | 23 | 1 | 6 | ||
236–250 CHSSALELLQEVIIV | 27 | 6 | 10 | 7 | 0 | ||
249–264 IVLERSESWNLKDLDI | 0 | 5 | 7 | 0 | 0 | ||
262–279 LDITSPELRSVCHVPGLK | 0 | 0 | 0 | 0 | 0 | ||
277–292 GLKKMLRTCAVHITLD | 83 | 49 | 0.049* | 40 | 24 | 6 | |
290–304 TLDPDTANPWLILSE | 0 | 7 | 7 | 0 | 0 | ||
302–317 LSEDRRQVRLGDTQQS | 10 | 2 | 7 | 0 | 0 | ||
314–328 TQQSIPGNEERFDSY | 0 | 9 | 0 | 9 | 0 | ||
326–340 DSYPMVLGAQHFHSG | 0 | 0 | 0 | 0 | 0 | ||
337–352 FHSGKHYWEVDVTGKE | 23 | 11 | 3 | 12 | 6 | ||
350–367 GKEAWDLGVCRDSVRRKG | 0 | 1 | 0 | 0 | 9 | ||
365–382 RKGHFLLSSKSGFWTIWL | 77 | 47 | 0.054 | 50 | 33 | 25 | |
380–396 IWLWNKQKYEAGTYPQT | 0 | 5 | 0 | 2 | 0 | ||
394–412 PQTPLHLQVPPCQVGIFLD | 18 | 1 | 3 | 10 | 0 | ||
411–423 LDYEAGMVSFYNI | 0 | 2 | 0 | 0 | 0 | ||
422–438 NITDHGSLIYSFSECAF | 16 | 2 | 0 | 0 | 0 | ||
436–451 CAFTGPLRPFFSPGFN | 13 | 7 | 13 | 10 | 0 | ||
447–463 SPGFNDGGKNTAPLTLC | 8 | 9 | 0 | 6 | 0 | ||
463–475 CPLNIGSQGSTDY | 0 | 7 | 7 | 1 | 0 | ||
Ro60 PROTEIN | 80 | 67 | 67 | 99 | 0.022* | 31 | |
1–23 MEESVNQMQPLNEKQIANSQDGY | 15 | 6 | 17 | 1 | 6 | ||
18–38 NSQDGYVWQVTDMNRLHRFLC | 32 | 11 | 20 | 1 | 0.097 | 0 | |
21–41 DGYVWQVTDMNRLHRFLCFGS | 64 | 27 | 0.044* | 23 | 38 | 0 | |
304–324 VCEKLCNEKLLKKARIHPFHI | 50 | 18 | 27 | 4 | 13 | ||
495–518 KLIVCGMTSNGFTIADPDDRGMLD | 10 | 24 | 0.058 | 7 | 11 | 0.079 | 13 |
524–538 TGALDVIRNFTLDMI | 10 | 17 | 3 | 9 | 0 | ||
La PROTEIN | 93 | 30 | <0.0001* | 40 | 68 | 13 | |