Skip to main content

Advertisement

Table 2 Allele frequencies of the nine regulatory single nucleotide polymorphisms in extracellular matrix proteases

From: Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study

Gene SNP Allele RA patients Controls OR p Sex-adjusted OR Change in transcriptiona
MMP1 -1607 1G/2G 2G 47.8 48.2 0.98 0.8 0.96 Up
MMP2 -1306 C/T T 24.5 20.3 1.27 0.01 1.27 Down
MMP3 -1171 6A/5A 5A 50.5 51.7 0.95 0.5 0.96 Up
MMP7 -181 A/G G 43.8 45.3 0.94 0.4 0.95 Up
  -153 C/T T 5.0 5.1 0.99 0.9 0.98 Up
MMP9 -1562 C/T T 14.3 13.6 1.05 0.6 1.02 Up
MMP13 -77 A/G A 68.0 65.6 1.13 0.2 1.09 Up
PLAT -7351 C/T T 36.4 32.1 1.21 0.03 1.20 Down
PAI-1 -675 5G/4G 4G 47.6 46.8 1.03 0.7 1.05 Up
  1. Frequency values for rheumatoid arthritis (RA) and controls are percentages.
  2. aReported up- or downregulation of gene expression determined by the mentioned allele. MMP, matrix metalloproteinase; OR, odds ratio; PAI, plasminogen activator inhibitor; PLAT, plasminogen activator, tissue type; SNP, single nucleotide polymorphism.