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Table 2 Allele frequencies of the nine regulatory single nucleotide polymorphisms in extracellular matrix proteases

From: Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study

Gene

SNP

Allele

RA patients

Controls

OR

p

Sex-adjusted OR

Change in transcriptiona

MMP1

-1607 1G/2G

2G

47.8

48.2

0.98

0.8

0.96

Up

MMP2

-1306 C/T

T

24.5

20.3

1.27

0.01

1.27

Down

MMP3

-1171 6A/5A

5A

50.5

51.7

0.95

0.5

0.96

Up

MMP7

-181 A/G

G

43.8

45.3

0.94

0.4

0.95

Up

 

-153 C/T

T

5.0

5.1

0.99

0.9

0.98

Up

MMP9

-1562 C/T

T

14.3

13.6

1.05

0.6

1.02

Up

MMP13

-77 A/G

A

68.0

65.6

1.13

0.2

1.09

Up

PLAT

-7351 C/T

T

36.4

32.1

1.21

0.03

1.20

Down

PAI-1

-675 5G/4G

4G

47.6

46.8

1.03

0.7

1.05

Up

  1. Frequency values for rheumatoid arthritis (RA) and controls are percentages.
  2. aReported up- or downregulation of gene expression determined by the mentioned allele. MMP, matrix metalloproteinase; OR, odds ratio; PAI, plasminogen activator inhibitor; PLAT, plasminogen activator, tissue type; SNP, single nucleotide polymorphism.