Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis?

Sedo, Aleksi; Duke-Cohan, Jonathan S; Balaziova, Eva; Sedova, Liliana R

doi:10.1186/ar1852

Table 1 Dipeptidyl peptidase IV/CD26 in rheumatoid arthritis

From: Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis?

	Peripheral blood CD3⁺CD26⁺	Peripheral blood CD4⁺CD26⁺	Synovial fluid CD3⁺CD26⁺	Serum/plasma DPPIV activity (μmol/min/l)	Synovial DPPIV activity (μmol/min/l)	Notes	Reference
Controls	12.9 ± 4.7					Ta1 antibody; all active with therapy	[47]
RA (active)	40.2 ± 10.6					Ta1 antibody; all active with therapy	[47]
Controls	58.2 ± 10.6					1F7 antibody; all active with therapy	[47]
RA (active)	72.0 ± 8.8					1F7 antibody; all active with therapy	[47]
Controls		12.3 ± 4.2				Ta1 antibody	[49]
OA		8.1 ± 2.0				Ta1 antibody	[49]
RA (inactive)		41.6 ± 23.1				Ta1 antibody	[49]
RA (active)		62.2 ± 10.1				Ta1 antibody	[49]
Controls	58.8 ± 9.0					1F7 antibody	[123]
OA			49.0 ± 11.0			1F7 antibody	[123]
RA (inactive)	60.6 ± 4.0					1F7 antibody	[123]
RA (active)	75.9 ± 10.0		36.3 ± 10.0			1F7 antibody	[123]
OA				36.7 ± 6.5 (CD26: 614 ± 157 ng/ml)	14.6 ± 4.4 (CD26: 247 ± 25 ng/ml)		[55]
RA							[55]
All				26.7 ± 9.9 (CD26: 473 ± 176 ng/ml)	16.1 ± 5.6 (CD26: 259 ± 80 ng/ml)		[55]
Non-inflammatory				31.8 ± 12.7 (CD26: 558 ± 195 ng/ml)		(n = 24; CRP < 20 mg/l)	[55]
Inflammatory				22.4 ± 4.7 (CD26: 404 ± 139 ng/ml)		(n = 17; CRP > 20 mg/l)	[55]
Controls				41.3 ± 4.7			[32]
RA (active)				34.5 ± 3.2			[32]
SLE				29.9 ± 6.5			[32]
OA					702.6 ± 41.2 mU/mg	Synovial fluid	[60]
RA (active)					549.6 ± 28.3 mU/mg	Synovial fluid	[60]
Controls				634 μmol/min/mol			[36]
Sjogren's syndrome				969 μmol/min/mol			[36]
SLE				650 μmol/min/mol			[36]
RA (active)				224 μmol/min/mol			[36]
OA					1.0 ± 1.4 nmol/min/mg	Synovial membranes	[54]
RA (active)
All grades					1.1 ± 1.1 nmol/min/mg	Synovial membranes	[54]
Grade 1 (0–10 ml fluid)					1.8 ± 1.4 nmol/min/mg	Synovial membranes	[54]
Grade 2 (10–20 ml fluid)					0.9 ± 0.6 nmol/min/mg	Synovial membranes	[54]
Grade 3 (> 20 ml fluid)					0.6 ± 0.5 nmol/min/mg	Synovial membranes	[54]

CRP, C-reactive protein; DPP, dipeptidyl peptidase; OA, osteoarthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus. Values for peripheral blood CD3⁺CD26⁺, peripheral blood CD4⁺CD26⁺ and synovial fluid CD3⁺CD26⁺ are shown as % gated lymphocytes.

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