First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled comparison with celecoxib [NCT00267215]

Table 2 Mean actual PID for 3-hour and 5-hour time points after first dose

Mean actual PID (10 mm VAS)	Lumiracoxib 400 mg (n = 144)	Celecoxib 200 mg (n = 145)	Placebo (n = 75)
Mean ± SD	19.8 ± 16.5**	16.8 ± 15.9^†	13.4 ± 12.9
Median (range)	16.0 (-15.5, 74.5)	15.5 (-31.0, 58.5)	12.5 (-9.5, 48.5)

**P = 0.004, pair-wise comparison versus placebo using least square means; ^†P = 0.069, pair-wise comparison versus placebo using least square means. PID, pain intensity difference; SD, standard deviation; VAS, visual–analogue scale.

ISSN: 1478-6362