Clinical disease activity of collagen-induced arthritis (CIA). DBA/1J mice were immunized with type II collagen and complete Freund's adjuvant (CFA) on days 0 and 21. The mice were then supplemented with THR0921 (50 mg/kg; open circles) or vehicle (closed circles) for 3 weeks. The clinical disease activity of CIA was determined every other day using a three-point scale for each paw. Data are expressed as mean ± standard error of the mean (n = 10/group; asterisks indicate p < 0.001 versus untreated-CIA mice).