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Figure 5 | Arthritis Research & Therapy

Figure 5

From: THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis

Figure 5

Steady state mRNA levels of the inflammatory cytokines IL-1β, monocyte chemotactic protein (MCP)-1, receptor activator of nuclear factor κB ligand (RANKL) and tumor necrosis factor (TNF)-α. Joints were isolated from mice on day 42, and total RNA was extracted. Cytokine gene expression was determined by real time PCR using the ΔΔCT method and is expressed as a percent of control (n = 5/group; the hash symbol indicates p < 0.01 from control; the dagger symbol indicates p < 0.05 versus untreated collagen-induced arthritis (CIA)).

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