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Table 4 Comparison of HLA class II phenotypes in serological subsetsa

From: In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype

HLA phenotype/serology

n (%)

p

p corr

OR (95% CI)

DRB1*03

    

   Synthetase

44 (84.6)

1 × 10-15

1 × 10-14

14.1 (6.3–35.2)

   PM-Scl

11 (100)

3 × 10-6

4 × 10-5

30.6 (4.4–1309.1)

DRB1*07

    

   Mi-2

14 (77.8)

4 × 10-6

5 × 10-5

11.1 (3.4–46.8)

DQA1*02

    

   Mi-2

14 (77.8)

9 × 10-6

5 × 10-5

11.6 (3.3–50.6)

DQA1*05

    

   Synthetase

42 (85.7)

7 × 10-9

4 × 10-8

9.5 (3.8–26.5)

   PM-Scl

11 (100)

0.0002

0.001

18.9 (2.6–814.9)

DQB1*02

    

   Synthetase

42 (85.7)

6.6 × 10-9

4 × 10-8

9.5 (3.8–26.5)

   Mi-2

15 (83.3)

7 × 10-4

0.004

7.5 (2.0–41.9)

   PM-Scl

11 (100)

0.0003

0.001

18.0 (2.5–777.4)

  1. aResults are versus controls. CI, confidence interval; OR, odds ratio; p, probability; pcorr, corrected probability.