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Table 5 Estimated haplotype frequencies of HLA class II loci

From: In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype

DRB1-DQA1-DQB1 haplotype

%

 

Controls

PM

DM

 

Other antibodiesa

  

Overall

Overall

AS

Mi-2

PM-Scl

U1-RNP

SRP

 

2n = 284

2n = 220

2n = 208

2n = 98

2n = 36

2n = 22

2n = 24

2n = 12

04-03-03

20.4

16.4

19.1

17.3

13.8

4.5

37.5

0

03-05-02b

16.5

33.6

24.5

43.9

8.3

54.5

12.5

4.1

02-01-06

13.7

9.1

9.6

10.2

8.3

4.5

20.8

25.0

01-01-05

10.6

11.8

13.5

7.1

22.2

9.1

16.7

8.3

13-01-06

10.2

6.4

5.8

6.1

0

4.5

1.0

8.3

07-02-02c

9.2

4.1

13.9

7.1

33.3

18.2

0

0

11-05-03

4.6

7.3

5.3

2.0

5.6

0

0

16.7

07-02-03

3.9

0.4

3.8

0

5.6

0

1.0

0

  1. Probabilities stated are corrected for multiple comparisons. Haplotypes found in less than 3% of controls are excluded from the table. aPolymyositis and dermatomyositis patients combined. bPM versus controls, p = 1.1 × 10-4, odds ratio (OR) 2.6 (95% confidence interval (CI) 1.6–4.0); AS versus controls, p = 7 × 10-10, OR 4.8 (CI 2.8–8.3); PM-Scl versus controls, p = 0.001, OR 6.1 (CI 2.2–16.5). cPM versus DM, p = 0.004, OR 0.3 (CI 0.1–0.6); Mi-2 versus controls, p = 0.002, OR 4.9 (CI 2.0–11.6). AS, anti-tRNA synthetase positive; DM, dermatomyositis; PM, polymyositis.