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Table 1 Frequency distribution of the PTPN22 1858C/T polymorphism

From: PTPN22polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease

  Pre-patients (n = 89) Controls (n = 360) χ2 P value OR 95% CI
  N % n %     
CC 54 60.7 289 80.3 15.21 0.00010 0.38 0.22–0.64
CT 33 37.1 68 18.9 13.54 0.00025 2.52 1.48–4.30
TTa 2 2.2 3 0.8 1.30 0.2586 2.74 0.31–20.46
CT + TT 35 39.3 71 19.7 15.21 0.00010 2.64 1.56–4.47
T allele 37 20.8 74 10.3 14.55 0.00013 2.29 1.45–3.61
  1. Frequencies of PTPN22 1858C/T genotypes and of the T allele were determined in individuals who later developed rheumatoid arthritis (pre-patients) and in controls.
  2. aFisher's exact test (two-sided). CI, confidence interval; OR, odds ratio.