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Table 1 Frequency distribution of the PTPN22 1858C/T polymorphism

From: PTPN22polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease

 

Pre-patients (n = 89)

Controls (n = 360)

χ2

P value

OR

95% CI

 

N

%

n

%

    

CC

54

60.7

289

80.3

15.21

0.00010

0.38

0.22–0.64

CT

33

37.1

68

18.9

13.54

0.00025

2.52

1.48–4.30

TTa

2

2.2

3

0.8

1.30

0.2586

2.74

0.31–20.46

CT + TT

35

39.3

71

19.7

15.21

0.00010

2.64

1.56–4.47

T allele

37

20.8

74

10.3

14.55

0.00013

2.29

1.45–3.61

  1. Frequencies of PTPN22 1858C/T genotypes and of the T allele were determined in individuals who later developed rheumatoid arthritis (pre-patients) and in controls.
  2. aFisher's exact test (two-sided). CI, confidence interval; OR, odds ratio.
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Arthritis Research & Therapy

ISSN: 1478-6362

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