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Table 1 Individual quantification of synovial stainings of cytokines, individual DAS28 values and ACR response rates

From: Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor

Patient Week TNFa IFN-γa IL-1αb IL-1ßb IL-15 neutr.b IL-15 non-neutr.b DAS28 ACR response (%)
1 0 0 1 0.9 0.5 0.8 5.1 6.71  
  9 0 1 0.1 0.8 3.2 13.2 6.34 0
2 0 0 2 2.5 0.4 1.5 3.4 6.00  
  9 0 0 1.2 0.3 2 12.6 4.43 20
3 0 1 1 0.9 7.3 0.3 15.1 7.91  
  9 0 0 0.4 0.1 0 2.1 5.41 50
4 0 0 1 1.2 0.1 0.1 0.6 4.94  
  9 0 2 2.1 33.1 4.6 7.1 4.41 20
5 0 1 1 0.1 0.6 11.3 3.6 5.95  
  9 1 1 2.1 0 1.2 13 2.90 70
6 0 1 1 0.2 2.5 2.7 0.4 7.39  
  9 0 1 0.8 4.4 5.4 7.5 1.79 70
7 0 0 0 0.8 0.7 4.4 2.5 4.83  
  9 0 0 0.1 0.1 0 0 4.23 0
8 0 0 0 2.1 0.5 9.5 16.7 5.64  
  9 0 0 3.3 1.1 6.6 15.1 4.73 0
9 0 0 0 4.9 4.3 4.6 11 5.62  
  9 1 0 3.7 4.4 2.8 6 3.91 20
  1. Individual quantification of stainings of synovial samples from nine patients with rheumatoid arthritis, before and after treatment with infliximab. aA semi-quantitative analysis was performed for tumour necrosis factor (TNF; mAb1 and mAb11) and IFN-γ, for which a semi-quantitative four-point scale was used: 0 = no positive cells, 1 = 1 to 10 positive cells, 2 = 11 to 100 positive cells, and 3 = more than 100 positive cells. bA computerized image analysis was performed for IL-1a, IL-1ß IL-15 neutralizing antibody and IL-15 non-neutralizing antibody; values are median percentages of the stained tissue area, with ranges in parenthesis.
  2. Individual DAS28 values and ACR response results are presented. ACR, American College of Rheumatology; DAS28, Disease Activity Score counted on 28 joints.