Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor

Table 1 Individual quantification of synovial stainings of cytokines, individual DAS28 values and ACR response rates

Patient	Week	TNF^a	IFN-γ^a	IL-1α^b	IL-1ß^b	IL-15 neutr.^b	IL-15 non-neutr.^b	DAS28	ACR response (%)
1	0	0	1	0.9	0.5	0.8	5.1	6.71
	9	0	1	0.1	0.8	3.2	13.2	6.34	0
2	0	0	2	2.5	0.4	1.5	3.4	6.00
	9	0	0	1.2	0.3	2	12.6	4.43	20
3	0	1	1	0.9	7.3	0.3	15.1	7.91
	9	0	0	0.4	0.1	0	2.1	5.41	50
4	0	0	1	1.2	0.1	0.1	0.6	4.94
	9	0	2	2.1	33.1	4.6	7.1	4.41	20
5	0	1	1	0.1	0.6	11.3	3.6	5.95
	9	1	1	2.1	0	1.2	13	2.90	70
6	0	1	1	0.2	2.5	2.7	0.4	7.39
	9	0	1	0.8	4.4	5.4	7.5	1.79	70
7	0	0	0	0.8	0.7	4.4	2.5	4.83
	9	0	0	0.1	0.1	0	0	4.23	0
8	0	0	0	2.1	0.5	9.5	16.7	5.64
	9	0	0	3.3	1.1	6.6	15.1	4.73	0
9	0	0	0	4.9	4.3	4.6	11	5.62
	9	1	0	3.7	4.4	2.8	6	3.91	20

Individual quantification of stainings of synovial samples from nine patients with rheumatoid arthritis, before and after treatment with infliximab. ^aA semi-quantitative analysis was performed for tumour necrosis factor (TNF; mAb1 and mAb11) and IFN-γ, for which a semi-quantitative four-point scale was used: 0 = no positive cells, 1 = 1 to 10 positive cells, 2 = 11 to 100 positive cells, and 3 = more than 100 positive cells. ^bA computerized image analysis was performed for IL-1a, IL-1ß IL-15 neutralizing antibody and IL-15 non-neutralizing antibody; values are median percentages of the stained tissue area, with ranges in parenthesis.
Individual DAS28 values and ACR response results are presented. ACR, American College of Rheumatology; DAS28, Disease Activity Score counted on 28 joints.

ISSN: 1478-6362