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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis

Figure 1

Synovial inflammation affects different compartments of juxta-articular bone. H & E-stained sections from the tarsal region of healthy 12-week-old (a) wild-type mice and (b) mice transgenic for human tumor necrosis factor (hTNFtg). The hTNFtg mice develop extensive synovial inflammation, cartilage damage and bone erosions. Three bone compartments affected by synovitis were analyzed in arthritic mice: the subchondral bone adjacent to the synovial inflammatory tissue (black arrow), the cortical bone channels in close vicinity of the inflamed areas (red arrow), and the endosteal bone surface distant from the inflammatory tissue (green arrows).

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