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Table 3 Association between the VDR haplotypes and hand osteoarthritis (OA)

From: Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

Joint genotypea Overall OA Symmetrical OA Osteophyte
  Yes/no Odds ratio (95% CI)b Yes/no Odds ratio (95% CI)b Yes/no Odds ratio (95% CI)b
Aatt 20/44 1.0 11/53 1.0 7/57 1.0
AATt 26/64 0.75 (0.35–1.61) 14/75 0.73 (0.29–1.83) 8/82 0.82 (0.2–2.56)
AATT 5/15 0.68 (0.20–2.38) 4/16 1.03 (0.26–4.08) 3/17 1.62 (0.33–7.92)
AaTt 43/111 0.75 (0.38–1.50) 28/125 0.99 (0.43–2.25) 5/149 0.26 (0.08–0.91)
AaTT 34/80 0.89 (0.43–1.84) 28/86 1.55 (0.67–3.54) 9/105 0.70 (0.23–2.13)
AaTT 32/69 1.00 (0.48–2.07) 25/76 1.63 (0.70–3.82) 7/94 0.61 (0.19–2.00)
At haplotype carriage 89/219 0.87 (0.58–1.30) 53/253 0.59 (0.38–0.93) 20/288 0.76 (0.38–1.52)
AT haplotype carriage 65/159 0.93 (0.62–1.41) 46/177 0.96 (0.61–1.52) 20/204 1.60 (0.78–3.27)
aT haplotype carriage 109/260 1.03 (0.67–1.59) 81/287 1.55 (0.94–2.56) 21/348 0.51 (0.25–1.03)
No aT haplotypec 51/123 1.0 29/144 1.0 18/156 1.0
One aT haplotyped 77/191 0.98 (0.62–1.54) 56/213 1.43 (0.84–2.42) 14/254 0.46 (0.21–1.00)
Two aT haplotypese 32/69 1.20 (0.67–2.15) 25/76 1.93 (1.01–3.70) 7/94 0.65 (0.24–1.75)
  1. aA, absence of a restriction site; a, presence of a restriction site; T, absence of a restriction site; t, presence of a restriction site. bOdds ratio and 95% confidence interval (CI) adjusted for age (years), height (cm), occupation (1 = dentists, 2 = teachers [reference group]), hormone therapy (1 = ever used, 2 = never used [reference group]), current body mass index (1 = high, 2 = moderate, 3 = low [reference group]), daily calcium intake (1 = high [reference group], 2 = moderate, 3 = low), coffee consumption (number of cups per day), alcohol consumption (number of portion per week), and smoking history (1 = never smoked [reference group], 2 = ever smoked). cNo aT haplotype = AATT + AATt + AAtt.dOne copy of the aT haplotype = AaTT + AaTt. eTwo copies of the aT haplotype = aaTT.