Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

Table 3 Association between the VDR haplotypes and hand osteoarthritis (OA)

Joint genotype^a	Overall OA		Symmetrical OA		Osteophyte
	Yes/no	Odds ratio (95% CI)^b	Yes/no	Odds ratio (95% CI)^b	Yes/no	Odds ratio (95% CI)^b
Aatt	20/44	1.0	11/53	1.0	7/57	1.0
AATt	26/64	0.75 (0.35–1.61)	14/75	0.73 (0.29–1.83)	8/82	0.82 (0.2–2.56)
AATT	5/15	0.68 (0.20–2.38)	4/16	1.03 (0.26–4.08)	3/17	1.62 (0.33–7.92)
AaTt	43/111	0.75 (0.38–1.50)	28/125	0.99 (0.43–2.25)	5/149	0.26 (0.08–0.91)
AaTT	34/80	0.89 (0.43–1.84)	28/86	1.55 (0.67–3.54)	9/105	0.70 (0.23–2.13)
AaTT	32/69	1.00 (0.48–2.07)	25/76	1.63 (0.70–3.82)	7/94	0.61 (0.19–2.00)
At haplotype carriage	89/219	0.87 (0.58–1.30)	53/253	0.59 (0.38–0.93)	20/288	0.76 (0.38–1.52)
AT haplotype carriage	65/159	0.93 (0.62–1.41)	46/177	0.96 (0.61–1.52)	20/204	1.60 (0.78–3.27)
aT haplotype carriage	109/260	1.03 (0.67–1.59)	81/287	1.55 (0.94–2.56)	21/348	0.51 (0.25–1.03)
No aT haplotype^c	51/123	1.0	29/144	1.0	18/156	1.0
One aT haplotype^d	77/191	0.98 (0.62–1.54)	56/213	1.43 (0.84–2.42)	14/254	0.46 (0.21–1.00)
Two aT haplotypes^e	32/69	1.20 (0.67–2.15)	25/76	1.93 (1.01–3.70)	7/94	0.65 (0.24–1.75)

^aA, absence of a restriction site; a, presence of a restriction site; T, absence of a restriction site; t, presence of a restriction site. ^bOdds ratio and 95% confidence interval (CI) adjusted for age (years), height (cm), occupation (1 = dentists, 2 = teachers [reference group]), hormone therapy (1 = ever used, 2 = never used [reference group]), current body mass index (1 = high, 2 = moderate, 3 = low [reference group]), daily calcium intake (1 = high [reference group], 2 = moderate, 3 = low), coffee consumption (number of cups per day), alcohol consumption (number of portion per week), and smoking history (1 = never smoked [reference group], 2 = ever smoked). ^cNo aT haplotype = AATT + AATt + AAtt.^dOne copy of the aT haplotype = AaTT + AaTt. ^eTwo copies of the aT haplotype = aaTT.

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