Table 1 Patterns of anti-Epstein–Barr virus (EBV) serologies observed in different disease states
From: Epstein–Barr virus and rheumatoid arthritis: is there a link?
Disease state | VCA | EBNA-1 | EBNA-2 | EA | References |
|---|---|---|---|---|---|
Early, acute primary EBV infection | IgA, IgM | Undetectable | ↑↑ | EA-D | [45,66] |
Primary infection (weeks to months) | IgG | ↑ | ↓ | EA-R | [45,67] |
Latent EBV infection in healthy host | Stable IgG | Stable | ↓ | Stable EA-R | [67] |
Reactivation/EBV replication | ↑↑ IgG | ↑↑ | ↑ | ↑ | [67-69,117] |
Nasopharyngeal carcinomaa | ↑↑ IgG, IgA | ↑ IgG, IgA | [70,118-120] | ||
Burkitt's lymphomaa | ↑↑ IgG | ↑ | ↑↑ | ↑ | [70,121] |
Multiple sclerosisa | ↑ | ↑ | ↑↑ | ↑ | [111,112] |
Systemic lupus erythematosusa | ↑ | ↑ | [113,114] | ||
Rheumatoid arthritis | ↑ | ↑ | ↑ | ↑ | [82-86,122] |