Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis

Table 2 Anti-CCP and IgM RF as predictors of radiographic joint destruction after 5 years

	Odds ratios (95% confidence intervals)
	Erosions	Joint space narrowing	Total
Anti-CCP2 (baseline)	1.91 (0.73–4.96)	1.64 (0.73–3.68)	1.90 (0.85–4.27)
Anti-CCP2 (first 3 years)	5.28 (1.45–19.2)^a	2.8 (1.15–6.78)^b	3.17 (1.30–7.69)^c
IgM RF (baseline)	0.45 (0.17–1.17)	0.57 (0.23–1.39)	0.67 (0.28–1.65)
IgM RF (first 3 years)	0.70 (0.21–2.25)	1.03 (0.35–3.0)	0.88 (0.30–2.58)

^aP = 0.007; ^bP = 0.03; ^cP = 0.01. IgM RF, immunoglobulin M rheumatoid factor.

ISSN: 1478-6362