Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs

Table 4 TNFα levels in high and low IL-10 producing patient users and nonusers of antimalarial treatment

IL-10 genotype	Healthy controls		Patients without antimalarial drugs		Patients with antimalarial drugs		p
	n	TNFα (pg/ml)^a	n	TNFα (pg/ml)^a	n	TNFα (pg/ml)^a
Low (AA/AG)	179	18.55 (49.27)	56	80.88 (201.48)	79	20.94 (84.97)	0.005
High (GG)	36	21.74 (58.42)	12	51.91 (51.75)	23	20.03 (134.44)	0.797

^aValues are median (interquartile range). Differences between users and nonusers of antimalarial therapy were evaluated by the Mann-Whitney U test. TNF, tumor necrosis factor.

ISSN: 1478-6362