Figure 1
From: Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis
Sheep meniscectomy model of early osteoarthritis (a) Schematic representation of left ovine tibial plateau demonstrating medial (MTP) and lateral (LTP) plateaux, further separated into regions normally covered (COV) and uncovered (UNCOV) by menisci. Full-thickness coronal sections were taken for histological evaluation as indicated by the broken line. (b) Photographs demonstrating typical osteoarthritic changes observed after lateral meniscectomy (MEN), including surface fibrillation (arrow) and osteophyte formation (arrowheads).