Figure 1

Ineffectiveness of re-employed courses in relation to dose of original course. Bars show the association of treatment termination of re-employed courses for ineffectiveness with the dose of the original methotrexate (MTX) course (total numbers shown in the bars). This relationship is shown for all re-employed courses (black bars; P = 0.02, by logistic regression), patients in whom MTX was re-employed at higher doses (grey bars; P = 0.43), and patients in whom MTX was re-employed at doses lower than or equal to the original courses (white bars; P = 0.01).