Figure 1From: Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technologyExperimental design. (a) Orthopedic samples. Three orthopedic biopsies (b1, b2, and b3) were taken from each of seven patients at random sites of the synovium. For patients 1 to 3 each biopsy was split into three parts. RNA from each sub-biopsy was hybridized in duplicate (b1.AA and b1.AB refer to biopsy 1, sub-biopsy A, technical replicates A and B, respectively) versus the reference. The average weight of the sub-biopsies was 33 mg. For patients 4 to 7, RNA from each biopsy was hybridized in duplicate (b1.A and b1.B: biopsy 1, technical replicates A and B, respectively) versus the reference. The average weight of the biopsies from patients 4 to 7 was 29 mg. (b) Arthroscopic biopsies. Two biopsies (b1 and b2) were taken from each of patients 8 and 11 to 13, and four from each of patients 9 and 10. Each biopsy was hybridized in duplicate versus the reference. The average weight of the arthroscopic biopsies was 19 mg.Back to article page