Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original magnification × 250. Biopsy 3 (b3) of patient 2 was available only for RNA extraction and not for staining. Biopsy 3 of patient 7 was not represented in the stainings or microarray analysis because of poor RNA quality. Biopsies 1 and 4 of patient 1, and biopsy 1 of patient 4, consisted mostly of adipose cells with some element of inflammatory cells. Biopsy 1 of patient 7 had a higher level of heterogeneity, and contained more vessels, than the others.