Comparative effects of allopurinol and benzbromarone on plasma urate levels. Initial and final plasma urate (Pur) after standard doses of urate-lowering drugs allopurinol (300 mg/day) or benzbromarone (100 mg/day). *For final versus initial plasma urate, P < 0.01 for allopurinol groups and P < 0.001 for benzbromarone group. Adapted from . Copyright 1998 with permission from BMJ Publishing Group.