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Table 3 Relationship between VDR genotype and clinical manifestation or laboratory profiles of SLE

From: Vitamin D receptor gene BsmIpolymorphisms in Thai patients with systemic lupus erythematosus

 

BB % (ratio) n = 2

Bb % (ratio) n = 22

bb % (ratio) n = 77

Total % (ratio)

Malar rash

50 (1/2)

54.54 (12/22)

54.54 (42/77)

54.45 (55/101)

Discoid rash

0 (0/2)

27.27 (6/22)

31.16 (24/77)

29.70 (30/101)

Photosensitivity

50 (1/2)

31.81 (7/22)

38.96 (30/77)

37.62 (38/101)

Oral ulcer

50 (1/2)

31.81 (7/22)

36.36 (28/77)

35.64 (36/101)

Arthritis

100 (2/2)

77.27 (17/22)

70.12 (54/77)

72.27 (73/101)

Serositis

50 (1/2)

18.18 (4/22)

9.09 (7/77)

11.88 (12/101)

- Pericardial effusion

0 (0/2)

13.63 (3/22)

7.79 (6/77)

8.91 (9/101)

- Pleural effusion

50 (1/2)

9.09 (2/22)

6.49 (5/77)

7.92 (8/101)

Renal disorder

50 (1/2)

68.18 (15/22)

64.93 (50/77)

65.34 (66/101)

Neurologic disorder

0 (0/2)

9.09 (2/22)

20.77(16/77)

17.82 (18/101)

- Seizure

0 (0/2)

9.09 (2/22)

15.58 (12/77)

13.86 (14/101)

- Psychosis

0 (0/2)

0 (0/22)

9.09 (7/77)

6.93 (7/101)

Hematologic disorder

    

- Leukopenia

50 (1/2)

40.90 (9/22)

44.15 (34/77)

43.56 (44/101)

- Thrombocytopenia

0 (0/2)

9.09 (2/22)

18.18 (14/77)

15.84 (16/101)

Immunologic disorder

    

- Anti-DNA

0 (0/2)

71.42 (15/21)

56.66 (34/60)

60.49 (49/81)

- Anti-Sm

0 (0/2)

57.14 (8/14)

32.60 (15/46)

37.09 (23/62)

ANA

100 (2/2)

100 (22/22)

98.68 (75/76)

99 (99/100)

- Homogenous pattern

50 (1/2)

50 (11/22)

48.68 (37/76)

49 (49/100)

- Rim pattern

0 (0/2)

40.90 (9/22)

44.73 (34/76)

33 (33/100)

- Nucleolar pattern

0 (0/2)

0 (0/22)

3.94 (3/76)

3 (3/100)

- Speckle pattern

50 (1/2)

45.45 (10/22)

59.21 (45/76)

56 (56/100)

  1. ANA = anti-nuclear antibodies; bb = excisable allele homozygote; Bb = heterozygote; BB = non-excisable allele homozygote; SLE, systemic lupus erythematosus; Sm = Smith; VDR, vitamin D receptor.