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Table 1 Modulation of BAFF mRNA expression with stimulation by cytokines in seven patients with pSS and seven controls

From: B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome

Condition Patients with pSS (n = 7) Controls (n = 7)
  BAFF mRNA/β-actin mRNA Fold increase over baseline p versus baselinea BAFF mRNA/β-actin mRNA Fold increase over baseline p versus baselinea
Baseline 0.44 ± 0.08    0.58 ± 0.2   
IL-10 0.9 ± 0.36 3.38 0.3 0.7 ± 0.28 1.57 0.3
TNF-α 0.7 ± 0.28 1.62 0.27 1.0 ± 0.3 3.15 0.25
IFN-α 9.2 ± 2.47 26.96 0.03 13.7 ± 9.1 19.06 0.2
IFN-γ 10.4 ± 1.65 25.01 0.008 12.2 ± 4.37 26.65 0.03
IFN-γ + TNF-α 23.7 ± 6.86 62.06 0.008 8.3 ± 3.18 17.66 0.06
  1. aPaired t test; bold values indicate significant difference (p < 0.05).
  2. Ratios of BAFF mRNA to β-actin mRNA are expressed as means ± SEM. BAFF = B cell-activating factor; TNF = tumor necrosis factor.