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Table 1 Modulation of BAFF mRNA expression with stimulation by cytokines in seven patients with pSS and seven controls

From: B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome

Condition

Patients with pSS (n = 7)

Controls (n = 7)

 

BAFF mRNA/β-actin mRNA

Fold increase over baseline

p versus baselinea

BAFF mRNA/β-actin mRNA

Fold increase over baseline

p versus baselinea

Baseline

0.44 ± 0.08

  

0.58 ± 0.2

  

IL-10

0.9 ± 0.36

3.38

0.3

0.7 ± 0.28

1.57

0.3

TNF-α

0.7 ± 0.28

1.62

0.27

1.0 ± 0.3

3.15

0.25

IFN-α

9.2 ± 2.47

26.96

0.03

13.7 ± 9.1

19.06

0.2

IFN-γ

10.4 ± 1.65

25.01

0.008

12.2 ± 4.37

26.65

0.03

IFN-γ + TNF-α

23.7 ± 6.86

62.06

0.008

8.3 ± 3.18

17.66

0.06

  1. aPaired t test; bold values indicate significant difference (p < 0.05).
  2. Ratios of BAFF mRNA to β-actin mRNA are expressed as means ± SEM. BAFF = B cell-activating factor; TNF = tumor necrosis factor.