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Table 2 Adenosine concentration in peritoneal exudates

From: Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3receptor activation in thioglycollate-induced peritonitis

 

Wild-type mice (nM ± SEM)

A2A knockout mice (nM ± SEM)

A3 knockout mice (nM ± SEM)

Control

118 ± 6 (n = 19)

110 ± 6 (n = 14)

133 ± 6 (n = 12)

Methotrexate (0.75 mg/kg/week)

178 ± 12* (n = 15)

162 ± 7** (n = 7)

214 ± 10† (n = 9)

  1. Wild-type mice, A2A receptor knockout mice or A3 receptor knockout mice were treated with either weekly injections of methotrexate (0.75 mg/kg) or saline control for 4 weeks prior to induction of inflammation. Inflammatory exudates were induced in the peritoneum of mice, as described. After 4 hours the exudates were collected and the adenosine levels quantitated. Wild-type data are a combination from both mouse strains. *P < 0.0001 vs wild-type control mice, Student's t test; **P < 0.0001 vs A2A knockout control mice, Student's t test; † P < 0.0001 vs A3 knockout control mice, Student's t test.
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Arthritis Research & Therapy

ISSN: 1478-6362

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