|
Experimental arthritis
| | |
|
IL-6 is required for the development of collagen induced arthritis
|
[31]
|
IL-6-/- and IL-6+/+ mice
|
|
IL-6 plays a key role in the development of antigen induced arthritis
|
[32]
|
IL-6-/- mice
|
|
Blockade of IL-6 receptor ameliorates joint disease in murine collagen induced arthritis
|
[33]
| |
|
Soluble IL-6 receptor governs IL-6 activity in antigen-induced arthritis: blockade of arthritis severity by soluble gp130
|
[34]
|
IL-6-/- mice
|
|
Colitis
| | |
|
Blockade of IL-6 trans-signalling suppresses T cell resistance against apoptosis in chronic intestinal inflammation
|
[30]
|
Neutralization of sIL-6R by a gp130-Fc fusion protein
|
|
IL-6 is required for the development of Th1 cell mediated murine colitis
|
[35]
|
C.B-17-scid mice transferred with CD45RBhigh CD4+ T anti-IL-6R mAb (MR16-1), used in a murine model of colitis
|
|
Modulating signaling
| | |
|
CIS3/SOCS3/SSI3 plays a negative role in STAT3 activation and intestinal inflammation
|
[36]
|
Development of colitis as well as STAT3 activation was significantly reduced in IL-6 deficient mice
|
|
Induction of SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
|
[37]
|
Recombinant adenovirus carrying the CIS3 cDNA injected periarticularly into the ankle joints of mice with antigen induced arthritis or collagen induced arthritis
|
|
Models of infection
| | |
|
IL-6 deficient mice are susceptible to:
| | |
|
Listeria monocytogenes
|
[38]
| |
|
Toxoplasma gondii
|
[39]
| |
|
Candida albicans
|
[40]
| |
