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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cells

Figure 3

Correlation between SF precipitate induced TNF-α production, IgG levels in SF precipitates, and RF (n = 32). Healthy PBMCs were stimulated with PEG precipitates from SF from 32 patients with RA. The stimulated cells were cultured for 20 hours at 37°C with 5% carbon dioxide. IgG levels in the SF precipitates correlated with (a) TNF-α production after SF PEG stimulation and (b) with RF measured in serum. (c) There was also a correlation between RF and TNF-α induced by SF PEG precipitates. Statistical analyses were performed with nonparametric tests to diminish the effect of outliers. PBMC, peripheral blood mononuclear cell; PEG, polyethylene glycol; RA, rheumatoid arthritis; RF, rheumatoid factor; SF, synovial fluid; TNF, tumour necrosis factor.

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