Figure 5From: Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cellsPEG precipitates from RA sera and SF induces TNF-α production via FcγRIIa.Anti-FcγRIIa and anti-FcγRIII antibodies were added to separate PBMC cultures before addition of PEG precipitates; culture was then continued for 20 hours. Anti-FcγRIIa antibodies blocked TNF-α production in cultures stimulated with PEG precipitates from RA sera and SF. One out of two experiments is shown. PBMC, peripheral blood mononuclear cell; PEG, polyethylene glycol; RA, rheumatoid arthritis; SF, synovial fluid; TNF, tumour necrosis factor.Back to article page