A promoter haplotype of the interleukin-18gene is associated with juvenile idiopathic arthritis in the Japanese population

Table 3 Numbers and frequencies of haplotype S01, S02 and S03

	S01 (%)	P ^a	S02 (%)	S03 (%)
Normal	131 (37.9)	-	165 (47.6)	50 (14.4)
JIA
All	36 (54.5)	0.011	25 (37.9)	5 (7.6)
Oligoarthritis	10 (83.3)	0.0021	2 (16.7)	0
Polyarthritis	10 (50.0)	NS	7 (35.0)	3 (25.0)
Systemic	16 (47.1)	NS	16 (47.1)	2 (5.9)
AOSD	30 (53.6)	0.028	20 (35.7)	6 (10.7)
RA	156 (47.6)	0.013	119 (36.3)	53 (16.2)
Collagen diseases	87 (42.6)	NS	89 (43.6)	28 (13.7)

^aThe frequency of S01 was compared with that of normal subjects and analyzed by Fisher exact probability test. AOSD, adult-onset Still's disease; JIA, juvenile idiopathic arthritis; NS, not significant; RA, rheumatoid arthritis.

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