Skip to main content

Table 2 Autoantibody levels in serum of 12-month old mice

From: The in vivoexpression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

Antibody

Apcs-/- (n = 44)

wt.DNase I. Apcs-/- (n = 21)

ash.DNase I. Apcs-/- (n = 21)

Anti-nucleara

1,280 (0–10,240)

2,560 (0–20,480)

320 (0–20,480)

Anti-dsDNAb

16.0 ± 8.9

9.2 ± 5.4

5.3 ± 3.5

Anti-chromatinb

8.8 ± 2.1

16.1 ± 5.1

10.6 ± 3.9

Anti-histoneb

56.7 ± 15.2

71.9 ± 17.0

18.6 ± 3.2 (p = 0.013)

Anti-ssDNAb

12.7 ± 2.7

10.1 ± 3.4

5.2 ± 2.1 (p = 0.008)

  1. aValues are stated as medians (range in parentheses) based on end-point dilution. bAntibody levels are expressed as arbitrary ELISA units (AEU) relative to a standard positive sample that was assigned a value of 100 AEU. The data are presented as mean ± standard error of the mean. Statistics were performed comparing autoantibody levels from transgenic mice to the control Apcs-/- mice, as stated in Materials and methods. Unless stated, there were no significant differences (p > 0.05) between the groups. dsDNA, double-stranded DNA; ssDNA, single-stranded DNA.