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Table 2 Autoantibody levels in serum of 12-month old mice

From: The in vivoexpression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

Antibody Apcs-/- (n = 44) wt.DNase I. Apcs-/- (n = 21) ash.DNase I. Apcs-/- (n = 21)
Anti-nucleara 1,280 (0–10,240) 2,560 (0–20,480) 320 (0–20,480)
Anti-dsDNAb 16.0 ± 8.9 9.2 ± 5.4 5.3 ± 3.5
Anti-chromatinb 8.8 ± 2.1 16.1 ± 5.1 10.6 ± 3.9
Anti-histoneb 56.7 ± 15.2 71.9 ± 17.0 18.6 ± 3.2 (p = 0.013)
Anti-ssDNAb 12.7 ± 2.7 10.1 ± 3.4 5.2 ± 2.1 (p = 0.008)
  1. aValues are stated as medians (range in parentheses) based on end-point dilution. bAntibody levels are expressed as arbitrary ELISA units (AEU) relative to a standard positive sample that was assigned a value of 100 AEU. The data are presented as mean ± standard error of the mean. Statistics were performed comparing autoantibody levels from transgenic mice to the control Apcs-/- mice, as stated in Materials and methods. Unless stated, there were no significant differences (p > 0.05) between the groups. dsDNA, double-stranded DNA; ssDNA, single-stranded DNA.