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Table 3 Renal histological assessment in 12-month old mice

From: The in vivoexpression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

  Histology gradea
  0 I II III IV Total
Apcs-/- 8 (18) 18 (41) 12 (27) 5 (11) 1 (2) 44
wt.DNase I. Apcs-/- 4 (19) 8 (38) 5 (24) 3 (14) 1 (5) 21
ash.DNase I. Apcs-/- 4 (19) 7 (33) 5 (24) 5 (24) 0 (0) 21
  1. aValues represent the number of mice (%) scored within that grade of glomerular hypercellularity. Grades 0 to IV are as described in Materials and methods. ash.DNase I, actin-resistant, salt-resistant and hyperactive mutant of DNase I; wt.DNase I, wild-type DNase I.