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Table 3 Renal histological assessment in 12-month old mice

From: The in vivoexpression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

 

Histology gradea

 

0

I

II

III

IV

Total

Apcs-/-

8 (18)

18 (41)

12 (27)

5 (11)

1 (2)

44

wt.DNase I. Apcs-/-

4 (19)

8 (38)

5 (24)

3 (14)

1 (5)

21

ash.DNase I. Apcs-/-

4 (19)

7 (33)

5 (24)

5 (24)

0 (0)

21

  1. aValues represent the number of mice (%) scored within that grade of glomerular hypercellularity. Grades 0 to IV are as described in Materials and methods. ash.DNase I, actin-resistant, salt-resistant and hyperactive mutant of DNase I; wt.DNase I, wild-type DNase I.
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Arthritis Research & Therapy

ISSN: 1478-6362

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