Anti-Sip1 C-ter antibodies in patients and healthy subjects. Anti-carboxy-terminal subunit of Sip1 (anti-Sip1 C-ter) antibodies in patients with Behçet's disease (BD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), vasculitis, inflammatory bowel disease (IBD), uveitis and from healthy donors. Median, quartiles, range, and possibly extreme values are indicated. The broken line represents the cutoff (mean + 2 standard deviations for the healthy controls). Outliers are represented as solid circles. (a) Box-whisker plot of anti-Sip1 C-ter IgM (§P < 10-4 for BD versus SLE, BD versus SSc, BD versus IBD, BD versus uveitis, BD versus healthy donors). (b) Box-whisker plot of anti-Sip1 C-ter IgG (†P = 0.001 for BD versus SLE; ‡P = 0.033 for BD versus vasculitis). (c) Box-whisker plot of anti-Sip1 C-ter IgA (*P < 10-4 for BD versus SLE, BD versus healthy donors, BD versus IBD; #P = 0.012 for BD versus vasculitis). OD, optical density.