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Table 4 Radiographic progression in RA patients according to the presence or absence of the PTPN22 1858T allele

From: Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients

  CC (n = 78) CT/TT (n = 45) P value
Larsen score at study entry 0 (0–2.5) 0 (0–4.7) 0.612
Larsen score after 1 year 2.0 (0–12.2) 11.5 (0–20.0) 0.061
Larsen score after 2 years 10.0 (0–26.0) 18.5 (2.0–34.5) 0.076
Larsen score after 4 years 16.0 (2.0–30.0) 24.0 (4.7–41.5) 0.136
Larsen score after 6 years 22.0 (10.7–39.2) 37.0 (15.25–52.7) 0.159
  1. Data are medians and interquartile range (IQR) for the comparison between PTPN22 risk allele negative and positive prospectively followed patients (n = 123). Levels of significance are given as determined by univariate analysis, power for all comparisons α < 0.8.