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Table 3 Results of the odds ratio calculation on the global sample (samples A and B combined)

From: Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis

Genotypes

Genotype distribution (n [%])

 

Odds ratio

95% Confidence interval

 

RA index (n = 200)

Pseudo-controlsa (n = 600)

  

S2/S2

14 (7)

17 (2.8)

20.5

7.1–58.8

S2/S3P

36 (18)

34 (5.7)

22.2

9.9–49.7

S2/L

44 (22)

120 (20)

5.9

2.9–12.2

S3P/S3P

15 (7.5)

31 (5.2)

8.2

3.2–21.2

S3P/L

58 (29)

164 (27.3)

4.4

2.3–8.4

L/L

33 (16.5)

234 (39)

1

-

  1. Alleles S2, S3P and L are defined according to amino acid sequence at positions 70–74, as described in Table 1. The L alleles are the low-risk alleles S1, S3D and X. The reference genotype is L/L. aPseudo-controls are the three other genotypes that could be formed by the parental genotypes.
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Arthritis Research & Therapy

ISSN: 1478-6362

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