Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production

Table 1 TNF production in co-cultures of SFL and THP-1 cells: effect of NK cell depletion

Sample source	TNF production (pg/ml)		Inhibition (%)
	SFL	SFL – NK
Rheumatoid arthritis (n = 5)	9,237 ± 4,062	2,472 ± 2,472	73.2
Spondyloarthropathies (n = 6)	2,680 ± 503	1,407 ± 442	47.5
Crystal-associated arthritis (n = 4)	3,557 ± 1,402	2,478 ± 1,196	30.3
Total (n = 15)	5,187 ± 1,735	2,059 ± 491	60.3^a

Where errors are shown, data are means ± SEM. SFL, synovial fluid lymphocytes;
SFL-NK, synovial fluid lymphocytes depleted of natural killer (NK) cells. ^aStatistical significance: p = 0.039, Mann-Whitney test.

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