Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production

Table 2 Blockade of CD18 and mIL-15 decreases CD69 expression and TNF production

Substance	Medium	Transwell	anti-CD18	anti-IL15
CD69 (RFI)	69.3 ± 14.9	21.9 ± 13^a	35.3 ± 10.4^a	39 ± 12.2^b
TNF (pg/ml)	9,687 ± 842	559 ± 139^a	3,594 ± 9,342^b	5,364 ± 841^b

The data shown are means ± SEM from eight independent experiments. m-IL-15, membrane-bound IL-15; RFI, relative fluorescence intensity. ^aStatistical significance: p < 0.01 by analysis of variance with Bonferroni multiple-comparison tests. ^bStatistical significance: p < 0.001 by analysis of variance with Bonferroni multiple-comparison tests.

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