From: Anti-inflammatory and immunosuppressive drugs and reproduction
Drug | FDA riska | Transplacental passage | Human teratogenicity | Fetal/neonatal adverse effects | Long-term effects in offspring | Impairment of fertility |
---|---|---|---|---|---|---|
Non-steroidal anti-inflammatory drugs | B/D | Yes | No | In late pregnancy, constriction of the ductus arteriosus, reduction of renal blood flow | Not studied | Cases of inhibition of follicle rupture |
Prednisone | B | Limited | Increase in oral clefts | Rare (cataract, adrenal insufficiency, infection) | Not studied | Not studied |
Dexamethasone | C | Yes | Not reportedb | Neurodevelopmental abnormalities | Not studied | Not studied |
Betamethasone | C | Yes | Not reportedb | Neurodevelopmental abnormalities ? | Not studied | Not studied |
Bisphosphonates | C | Not studied | Not reported | Two cases of hypocalcaemia in the newborn infant | Not studied | Not studied |