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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis

Figure 1

Intra-articular expression of human IL-10 (hIL-10), viral IL-10 (vIL-10), and mutant human IL-10 (mut.hIL-10). Twenty-four hours post antigen-induced arthritis (AIA) induction, 5 × 109 particles of Ad.hIL-10, Ad.vIL-10, Ad.mut.hIL-10 or adenovirus expressing enhanced green fluorescent protein (Ad.eGFP; as control) were injected into knees. At days 3 and 7 after injection of the virus, the knees were lavaged and levels of hIL-10, vIL-10, and mut.hIL-10 expression determined in the recovered lavage fluids by a cytokine ELISA kit. All values shown represent the mean ± standard error of the mean.

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Arthritis Research & Therapy

ISSN: 1478-6362

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