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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis

Figure 2

Effect of human IL-10 (hIL-10), viral IL-10 (vIL-10), and mutant human IL-10 (mut.hIL-10) on leukocytic infiltration. Twenty-four hours after antigen-induced arthritis (AIA) initiation, rabbits received Ad.hIL-10, Ad.vIL-10, Ad.mut.hIL-10 or adenovirus expressing enhanced green fluorescent protein (Ad.eGFP). On days 3 and 7 after adenovirus delivery, the knees were lavaged and the number of leukocytes counted in the recovered lavage fluid using a hemocytometer. Naïve rabbit control leukocyte levels averaged about 104 cells/ml. All values are represented as the mean ± standard error of the mean. Asterisks denote values that differ at p < 0.05 (Student's t test).

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Arthritis Research & Therapy

ISSN: 1478-6362

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