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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis

Figure 4

Histological analysis of synovial tissue recovered from the rabbit knees. Twenty-four hours after antigen-induced arthritis (AIA) induction, rabbits received either Ad.hIL-10, Ad.vIL-10, Ad.mut.hIL-10 or Ad.eGFP. On day 7 after the adenoviral delivery, the rabbits were sacrificed, and synovial tissue harvested, fixed, sectioned, and stained with hematoxylin and eosin. (a) Synovium from a naïve control rabbit knee. (b) Synovium from an AIA rabbit knee that received Ad.eGFP as an inflamed control. (c) Synovium from an AIA rabbit knee that was treated with Ad.hIL-10. (d) Synovium from an AIA rabbit knee that was treated with Ad.vIL-10. (e) Synovium from an AIA rabbit knee that was treated with Ad.mut.hIL-10. hIL-10, human IL-10; mut.hIL-10, mutant human IL-10; vIL-10, viral IL-10; eGFP, enhanced green fluorescent protein.

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